HSV - Herpes Simplex Viral Vector

Molecular Biology of the HSV

Herpes viruses are large, enveloped DNA viruses comprising a genome of double-stranded DNA 150 kb in length located within the viral capsid and encoding some 100-200 genes (see diagram one). Typically, glycoprotein C mediates viral entry by interacting with heparin sulphate, thus initiating a series of interactions ultimately resulting in entry into the cell. Once in the cytoplasm, the viral capsid is transported to nuclear membrane pores where it injects its genome through its capsid portal.