Integrating viral vectors hold great promise as gene transfer vectors for gene therapy purposes because they allow maintaining long-term expression of the therapeutic transgene throughout cell divisions. However, many issues related to integration of the provirus remain as a substantial risk for patients. The use of chromatin insulators has been proposed as a possible solution to problems raised by the integration of the vector.
Gene Therapy Technology
Gene therapy has developed greatly and the amount of patients treated in various clinical trials has continued to increase during the last decade (with 89 approved trials 2007, http://www.wiley.co.uk/genmed/clinical/).